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IV delivery enables direct, concentrated dosing , bypassing liver breakdown

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Reactive Oxygen Species (ROS) are increased by the consumption of sugars and oxidized vegetable oils, smoking, alcohol, exposure to environmental toxins, high or chronic emotional stress, circadian rhythm dysregulation (poor sleep), lack of exercise, infections, and a lack of antioxidant intake

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These pathways may converge on genomic responses by phosphorylating VDR or its coactivators ( In metabolic tissues, these pathways integrate to maintain homeostasis